Wu Sangui (Chinese: 吳三桂; pinyin: Wú Sānguì; WG: Wu San-kuei) (1612 - October 2, 1678) was a Ming Chinese general who opened the gates of the Great Wall of China at Shanhai Pass to let Manchu soldiers into China proper, leading to the ultimate destruction of the Ming Empire and the establishment of the Qing Empire. His courtesy name was Changbai (長白) or Changbo (長伯).

Wu was born in Gaoyu (高郵), Jiangsu Province to Wu Xiang (襄). He was rewarded the position of Pingxi King (平西王) in Yunnan, but later betrayed the Qing Empire in 1674 and started the Revolt of the Three Feudatories, declaring himself the "All-Suppress-Military Generalissimo" (天下都招討兵馬大元帥 Tianxia-dou-zhaotao-bingma Dayuanshuai). The following year, he declared himself the Emperor of Zhou (周帝), with the era name of Zhaowu (昭武), and capital in Dingtianfu , which was Hengzhou (衡州, now Hengyang, Hunan).

His concubine was Chen Yuanyuan. He died of illness in Hengzhou, Hunan province, and was succeeded by his grandson Wu Shifan (吳世藩).