Three United States Navy ships have been named Buffalo, the first after the large mammal, the others after the city of Buffalo, New York.

• The first Buffalo was a 3-gun sloop purchased April 1813 at Philadelphia and attached to the Delaware Flotilla . Under the command of Lieutenant Samuel Angus , she took part in the flotilla's 29 July 1813 attack on British frigate HMS Junon and sloop-of-war HMS Martin . She was sold at Philadelphia 12 August 1816.
• The second Buffalo was an auxiliary cruiser purchased for use in the Spanish-American War.
• The third Buffalo (SSN-715) is the 25th Los Angeles-class nuclear attack submarine.

Light cruiser hull CL-84 was to have been named Buffalo, but was cancelled 16 December 1940.

Hull CL-99 was also to have been a Buffalo, but was converted into the light aircraft carrier Bataan (CVL-29).

Hull CL-110 was yet another attempt to have a cruiser Buffalo, but was cancelled 12 August 1945.