Tlaxcala is the name of both a state in Mexico and that state's capital city. This article is about the city. For the state, see: state of Tlaxcala.

The city of Tlaxcala is the capital and chief center of population of the Mexican state of the same name. The city is located at and it reported a population of 73,184 in the 2000 census.

The city, though originally settled by native peoples, was officially "founded" in 1520 by Hernán Cortés – with whom they had an alliance against their former Aztec oppressors.