Anna (or Ti'ana (D'ni: Tee'ahnah/[Ti'ana]), as the D'ni preferred to call her, as it was more convenient for them to pronounce), was Aitrus' wife and the first human to descend to the D'ni city proper. As many D'ni were reluctant about strangers, she was met with skepticism, but was later accepted into the D'ni society, and eventually gained legal status as a D'ni (cf. Myst: The Book of Ti'ana).

Ti'ana was also the mother of Gehn and grandmother of Atrus. She taught and raised Atrus throughout most of his childhood, and later protected him from his father Gehn, as told in Myst: The Book of Atrus.

Ti'ana died on Myst Island and was buried there.

The name Ti'ana meant "story-teller", and was given to her by Aitrus after she told him of human superstition of a subterranean hell — something Aitrus as an inhabitant of a subterranean Cavern found very amusing.