There are several meanings of Three Sisters.

1. The Three Sisters are a cluster of volcanoes in Oregon, USA.
2. The Three Sisters are a large rock formation in the Blue Mountains near Sydney, Australia.
3. The Three Sisters are a trio of peaks near Canmore, Alberta.
4. The Three Sisters is a group of three rivers in Ireland.
5. The Three Sisters are the three basic agricultural crops of Native Americans in North America.
6. The Three Sisters or Drei Schwestern is a peak in Liechtenstein.
7. Three Sisters is a variety of tomato
8. The Three Sisters is a play by Anton Chekhov.
9. Three Sisters is a 1970 movie adaptation of the Chekhov play, directed by Laurence Olivier.
10. Three Sisters is a 2000-2001 television series aired on NBC.
11. Three Sisters is a town in the Northern Cape Province of South Africa.