Brian Setzer (born April 10, 1959 in New York) is an American guitarist and songwriter.

In the 1980s, Setzer fronted the popular rockabilly band, The Stray Cats. The Stray Cats caught America's attention with the 1982 album Built for Speed, which included the two Top Ten hits, "Rock This Town" (#9) and "Stray Cat Strut" (#3), as well as with the follow-up 1983 album Rant 'N Rave, which included the two successful singles "(She's) Sexy + 17" (#5), and "I Won't Stand In Your Way" (#35).

In the 1990s, Setzer led a comeback of sorts for swing music and big band music, when he formed The Brian Setzer Orchestra. This group had a hit in "Jump, Jive, and Wail" around the same time songs like The Cherry Poppin' Daddies' "Zoot Suit Riot" had been received favorably in mainstream America.