The Merv Griffin Show was a long-running American television talk show, starring singer Merv Griffin. The series ran from 1962 to 1986.

A typical show would begin with a short introduction by Griffin, during which he would sometimes sing a song. Various celebrity guests would follow, conversing with Griffin. Usually the show originated in Los Angeles, but Griffin often taped the show in Las Vegas.

The well-known sitcom, Seinfeld spoofs the show in Season 9, Episode 6, “The Merv Griffin Show”, in which Cosmo Kramer pretends that he hosts his own talk show using discared material from the Merv show.