The Tanana Valley is the lowland region in central Alaska in the United States, on the north side of the Alaska Range where the Tanana River emerges from the mountains.

The region suffers great extremes of temperature during the year. During the winter months, the air is prone to stratification leading to thick fogs. During the summer, the surrounding plains are generally marshlike.

The Tanana Valley is the most populated area of Alaska north of the Alaska Range. Communities in the Tanana Valley include

• College
• Ester
• Fairbanks (largest)
• Fox
• Manley Hot Springs
• Nenana
• North Pole
• Two Rivers