Published in 1945, Stuart Little became E. B. White's first children's story. It is the tale of a young New Yorker named Stuart Little who had the "shy, pleasant manner of a mouse" and in Garth Williams' illustrations does look like a mouse. Stuart is good natured, thoughtful, practical, modest and courageous and goes through many adventures while living with his family in New York City. Eventually, he sets out on a journey to find his friend Margalo, a bird saved by Stuart's family. According to White, the idea for this story came in a dream while he was sleeping on the train.

The story was adapted by M. Night Shyamalan into a film, also called Stuart Little, which combines live-action with computer animation that defined the state-of-the-art in 1999. Its popularity ensured a sequel, Stuart Little 2, in 2002. The computer-animated Stuart was voiced by Michael J. Fox. A cartoon TV series resulted, produced for HBO Family.

Julie Harris has recorded the original Stuart Little as an audiobook.

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"When Mrs. Frederick C. Little's second son arrived, everybody noticed that he was not much bigger than a mouse."

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