To spike a gun is to render it unusable. The term originally referred to muzzle-loading cannon. Driving an iron hand-spike (part of the gun's equipment) into the touch-hole on the cannon's breech would enlarge the hole and leave the gun unusable until repaired, or bushed, an hour or more work.
To "spike" a drink is a term meaning to add something to it, usually adding to the effect of an alcoholic drink, and often unknown to the person drinking it. See also date rape drugs.
An unbranched, indeterminate inflorescence (Botanical) with sessile flowers arranged along the axis. Compare with raceme.
The Spire of Dublin, a massive needle-like structure erected in Dublin in 2003, is widely known as The Spike
An Israel-developed guided anti-tank missile spike (missile) .