The Shasta Cascade region of California is located in the northeastern section of the state bordering Oregon and Nevada, north of the Central Valley and the Sierra Nevada mountain range. The area is centered on Mount Shasta in the California Cascade Range, near the Trinity Alps . Mount Shasta is a dormant volcano, nearby Lassen Peak is recently active.

The civic "capital" of the Shasta Cascade area is Redding; other major cities are Alturas, Biggs, Chico, Oroville and Yreka. Counties included in the Shasta Cascade region include Butte, Lassen, Modoc, Plumas, Shasta, Siskiyou, Tehama and Trinity.

There are seven national forests in the area: Klamath National Forest , Lassen National Forest , Mendocino National Forest, Modoc National Forest , Plumas National Forest and Shasta-Trinity National Forests , as well as the Lava Beds National Monument.

Geologically, this region is similar to the main Cascade Range, dominated by volcanism.