• Santa Barbara is the county seat and principal city of Santa Barbara County, on the Pacific coast of California. It is named for Mission Santa Barbara. It is also home to the University of California, Santa Barbara.

• Santa Barbara was a soap opera which aired on NBC from 1984 to 1993.

• Santa Bárbara is both a canton in the Heredia province of Costa Rica and its capital city.

• Santa Bárbara' is a parish name that is also known as Manadas in the Azores.

• Serra de Santa Barbara is a mountain range in Terceita in the Azores. Its elevation is 1,022 m.

• Barbara was said to have been a martyr in the third century.

There are other places that are named Santa Bárbara:

• Santa Bárbara , a parish in the district of Lourinhã
• Santa Bárbara, a parish in the district of Ponta Delgada
• Santa Bárbara, a parish in the district of Ribeira Grande
• Santa Bárbara, a parish in the district of Vila do Porto

• Santa Bárbara , Bahia
• Santa Bárbara , Minas Gerais

• Santa Bárbara , a parish in the island of Brava, Cape Verde