San Lorenzo is Italian and Spanish for Saint Lawrence.

• Basilica di San Lorenzo di Firenze, a church in Florence designed by Filippo Brunelleschi.
• San Lorenzo, Argentina , is a city in the province of Chaco
• San Lorenzo, Paraguay , is a satellite city at the east of Asunción.
• San Lorenzo, Puerto Rico
• San Lorenzo Tenochtitlán is an ancient center of the Olmec culture, in today's Veracruz state of Mexico.
• San Lorenzo, Oaxaca , in the Mexican state of Oaxaca
• San Lorenzo, Italy (pop: 3,393), is a commune in Calabria.
• San Lorenzo, California, is a town located in Alameda County, California, USA.
• San Lorenzo de El Escorial is a municipality in the province of Madrid, Spain.
• San Lorenzo River is a river in California, USA.
• Mount San Lorenzo (2270 m), in Sierra de la Demanda , is the highest peak in La Rioja, Spain.
• Club Atlético San Lorenzo de Almagro, a prominent Argentine football club.
• San Lorenzo is also the name of a fictional Caribbean island nation in the novel Cat's Cradle by Kurt Vonnegut.