Renfrew-Nipissing-Pembroke is a riding in the eastern part of the Canadian province of Ontario. It is currently represented by Cheryl Gallant (Conservative) federally and John Yakabuski (Progressive Conservative) provincially.

The population of the riding (2001) is 93,605.

Renfrew-Nipissing-Pembroke includes all of Renfrew County and a small section of Nipissing District around Algonquin Provincial Park.

The largest community in the riding is the city of Pembroke; other communities include Arnprior, Barry's Bay , Chalk River , Cobden , Deep River, Eganville , Killaloe , Petawawa and Renfrew.

Until recently, the riding was a Liberal stronghold both federally and provincially, however, a growing agricultural and religious base has turned this into one of the most conservative areas in Ontario.