Pine Creek is a town in the Katherine region of the Northern Territory, Australia. According to the 2001 Australian census 665 people live in Pine Creek.

The town was founded in 1870 during the construction of the Overland Telegraph line from Adelaide to Darwin, in 1871 wokers digging holes for the telegraph line found gold in the soil, triggering another Australian gold rush. The Northern Territoy Railway was built between Pine Creek and Darwin, reaching Pine Creek in 1889 and closing in 1976. Pine Creek Goldfields Limited opended an open cut gold mine in the region in 1985.