Pennsylvania Station (generally referred to as Penn Station) is the main train station in Baltimore, Maryland. Designed by McKim, Mead & White, it was constructed in 1911 in the Beaux-Arts style of architecture at its present location at 1515 N. Charles Street, between the Mount Vernon and Station North neighborhoods several miles north of downtown and the Inner Harbor.

Penn Station is served by Amtrak, MARC, and the Maryland Transit Administration's light rail system. It is the fifth busiest rail station in the United States by number of passengers served.