PBR is a three-letter acronym that may refer to

• Patrol Boat, Rigid, a type of river patrol boat used by the US Navy during the Vietnam War
• plastic baton round, a type of non-lethal projectile more commonly known as the plastic bullet
• Pabst Blue Ribbon, a brand of beer
• Pharma Bio Research, a Dutch drug research company
• Pink Backpack Rebellion, a computer gaming clan which dominated Command & Conquer Renegade, and has since moved on to own in Counterstrike: Source