Mount Vernon is a neighborhood located just to the north of downtown Baltimore, Maryland. It is one of the city's oldest neighborhoods. The name derives from the home of George Washington; the Washington Monument , a massive pillar commemorating the first president of the United States, is the defining feature of the neighborhood.

Mt. Vernon lies just to the north of downtown. Generally speaking, it is bounded by Centre Street to the south, Howard Street to the west, and the Jones Falls Expressway to the north and east, though the northern half of this area is often referred to as Midtown. The Inner Harbor is about half a mile south of Centre Street.

Mt. Vernon is home to some of the most beautiful and well-preserved 19th century architecture on the East Coast of the United States. The centerpiece of the neighborhood is the area around the Washington Monument, where stately palatial homes face onto a four small parks that surround the monument. The parks, which have survived almost intact, are considered to be the finest existing urban landscapes by the bueaux-arts architectural firm of Carrere & Hastings, who also designed the New York Public Library and the residence that houses the Frick Collection. Elsewhere in the neighborhood are many older apartment buildings and three- and four-story rowhouses; many of the latter were originally single-family dwellings that have now been broken up into multiple apartments.

The neighborhood also has a reputation as a gay village. Although it is by no means an exclusively gay community, many of Baltimore's most prominent gay bars are in Mt. Vernon, and the area hosts the annual Gay Pride festival.

Being close to downtown, Mt. Vernon is well-served by public transit. Most area major bus routes head through the neighborhood on their way to the financial district. The Baltimore Light Rail line runs down Howard Street on the west edge of the neighborhood, and the Metro Subway runs beneath Eutaw Street a block west of that; both have stations within easy walking distance of the neighborhood. Penn Station is also a quick walk across the JFX to the north.