Mount Hopkins is located in the Southern Alps of New Zealand's South Island. It lies 25 kilometres to the southwest of Mount Cook, and rises to 2682 metres.

Several rivers have their sources on or close to the slopes of Mount Hopkins, notably the Landsborough River to the west, the Dobson River to the east, and Hopkins River to the south.

At Mount Hopkins, the traditional boundaries of Otago, Canterbury and the West Coast regions meet. It is the northernmost point of Otago.