Molise is a region of south central Italy, the second smallest of the regions. It was formerly (until 1963) part of the region of "Abruzzi e Molise" (with Abruzzo) and now a separate entity. It borders Abruzzo to the north-west, Lazio to the west, Campania to the south, Puglia to the south-east and the Adriatic Sea to the north-east.

The region covers 4,438 km² and has a population of about 330,000. In the region there are two ethnic minorities: the Molisan Croatians (2.500 people speak an old dialect of the Croatian-Dalmatian language) and the Molisan Albanians (they speak an old dialect of the Albanian language, it is now very different from the today Albanian spoken in the otherside of the Adriatic Sea) they are orthodox.

The regional capital is Campobasso. The region is divided into two provinces: Campobasso and Isernia.

Other important towns: Termoli