Minatitlán is a city in the state of Veracruz, Mexico. It serves as the municipal seat for the surrounding municipality of the same name, which borders on the municipalities of Las Choapas, Coatzacoalcos, and Jáltipan ; it stands on the railway and on Federal Highway 121.

It is a sister city of Minatitlán in the state of Colima, on the other side of the country.

One of Mexico's six oil-refining facilities is located there. The refining complex processes 180,000 barrels a day and produces diesel, fuel oil, and gasoline. The local economy basically depends on the petroleum industry, but corn, fruits, sugar, and rice are also cultivated in the area.