Manduessedum was a Roman fort settlement in modern day Warwickshire in England.

The fort was founded in around c AD 50-AD 60 on the Watling Street Roman road. The final battle between the rebel queen of the Britons Boudicca at the Battle of Watling Street may have taken place near Manduessedum. The British forces were defeated by the Roman general Suetonius Paullinus.

Manduessedum developed into a civilian settlement and was the centre of a pottery making industry. Up to 30 kilns dating from the Roman period have been found in the area.

The modern village of Mancetter near the town of Atherstone is built upon the site of Manduessedum.