• For the burgh of Macduff in Scotland see Banff and Macduff
• For the Scottish clan of MacDuff see Clan MacDuff

Macduff is a fictional character in Shakespeare's play Macbeth.

He is the Thane of Fife, and flees to England with the son of King Duncan when the king is slain by Macbeth. He later fights Macbeth during a war to take back the throne; it has been prophecied that Macbeth cannot be killed by any "man of woman born," but Macduff reveals he was born by Caesarean section, and kills him.