Louis McLane (May 28, 1786-October 7, 1857) represented the state of Delaware in both the United States House of Representatives and the U.S. Senate and served as the Secretary of the Treasury and later the Secretary of State under President Andrew Jackson.

McLane was born in Smyrna, Delaware in 1786. He served as Secretary of State from May 29, 1833 until June 30, 1834.

As Secretary of State, McLane managed the first major reorganization of the Department of State, establishing seven new bureaus. His organization was basically retained until Ulysses S. Grant's Secretary of State, Hamilton Fish, reorganized in response to a reduction in the number of State Department staff.

McLane died in Baltimore, Maryland in 1857.

|- style="text-align: center;" | width="30%" |Preceded by:
Edward Livingston | width="40%" style="text-align: center;" |United States Secretary of State
May 29, 1833 – June 30, 1834 | width="30%" |Succeeded by:
John Forsyth