Lou Antonio (born January 23, 1934 in Oklahoma City, Oklahoma, USA) is an actor and TV director. Two of the most notable movies he has acted in are Cool Hand Luke and America, America. He also starred in two short-lived TV series, Dog and Cat, and Makin' It.

Antonio's only recurring TV guest role character was on Here Come the Brides, but he made multiple appearances as different characters on 1960s and 1970s series like The Rookies, Mission: Impossible, Gunsmoke, The Fugitive, Twelve O'Clock High, Star Trek: The Original Series, and The Defenders.

As a director, he has mostly worked on TV movies such as Mayflower Madam, and TV series such as The Rockford Files, Dawson's Creek, CSI: Crime Scene Investigation, and The West Wing.

Lou was married to fellow actor Lane Bradbury , and his brother Jim Antonio is also an actor.

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