LISA is:

• The Laser Interferometer Space Antenna
• The LISA Annual System Administration Conference
• The Apple Lisa computer, the precursor to the Apple Macintosh.
• Lisa Simpson, a cartoon character in the television series, The Simpsons
• LISA automated testing, a software testing application from iTKO | Load-bearing Internet-based Simulator Application.
• An acronym for Look In Side Always
• Lisa Loeb, female pop singer/songwriter.