Leo Joseph Nomellini (b. June 19, 1924, in Lucca, Italy, d. October 17, 2000 was a hall of fame football player with the San Francisco 49ers. He was a two-time All-America at Minnesota and the 49ers' first-ever NFL draft choice in 1950.

Nomellini was an iron man who played every 49ers game for 14 seasons, 174 regular-season and 266 pro games in all. During his career he played both defensive and offensive tackle, winning all pro honors at both positions. He was selected to the All-NFL team six times, two years on offense, four years on defense. Nomellini was named NFL's all-time time as a defensive tackle.

During the off-season Nomellini often wrestled professionally.