John Thompson may refer to:

• Sir John Sparrow David Thompson, Prime Minister of Canada from 1892 to 1894.
• John Thompson (basketball coach)
• John Thompson III
• John "Cat" Thompson , basketball player
• John Griggs Thompson, mathematician
• John W. Thompson, CEO of Symantec
• John W. Thompson , mayor of Davenport, Iowa
• John A. "Snowshoe" Thompson , 19th century mail carrier across the Sierras
• John B. Thompson American explorer and politician.