There have been a number of people named John Locke:

• John Locke was a 17th century philosopher concerned primarily with society and epistemology.
• John Locke is also a musician and a former member of the jazz-hard rock band, Spirit.
• Locke (a conscious nod to John Locke) was used as an online pseudonym by Peter Wiggin and Valentine Wiggin in the Ender's Game series of books by Orson Scott Card. (see Demosthenes)
• John Locke was the name of a character on the television show Lost who encourages other characters to think for themselves and use reason and evidence.