Jerzy Radziwiłł (1480-1541) was a Polish szlachcic.

He was Podczaszy of Lithuania since 1510, voivode of Kijów Voivodship since 1510, Field Hetman of Lithuania in 1521, castellan of Troki since 1522, castellan of Wilno since 1527, Court Marshal since 1528, Grand Hetman of Lithuania since 1531, Starost grodzieński, Namiestnik wieleński, mejszagolski, merecki, uciański, mozyrski, lidzki, skidelski, bielicki, kryński and ozierski.

Known for his military achievements and as a talented politician. He took part in various conflicts against Russian Empire, Cossacks and Tatars.

In 1526 as a member of the Lithuanian Council of Lords he unsuccesfully petitioned king Zygmunt I Stary to create a separate Kingdom of Lithuania under the reign of Zygmunt's I son, Zygmunt II August. In 1530s acting with his cousin Jan Radziwiłł he was in almost total control of Lithuania's internal affairs.

Member of Radziwiłł family. Like his predecessors, Jerzy also managed to increase his estate, which after his death was inherited by his only son Mikołaj 'Rudy' Radziwiłł. He had two daughters, of which the younger Barbara Radziwiłł became mistress and later queen to King Zygmunt II August of Poland, which greatly strenghtened the Radziwiłłs family's position in Poland and Lithuania.