Ironweed is a 1983 novel by William Kennedy. Part of Kennedy's "Albany Cycle " of novels, Ironweed tells the story of an alcoholic, wandering man and woman during the Great Depression. The novel received the 1984 Pulitzer Prize for Fiction.

A film version was adapted by Kennedy in 1987 from his novel. It was directed by Hector Babenco . It stars Jack Nicholson, Meryl Streep, Carroll Baker, Michael O'Keefe , Diane Venora , Fred Gwynne, Tom Waits and Nathan Lane.

The film was nominated for Academy Awards for Best Actor in a Leading Role (Nicholson) and Best Actress in a Leading Role (Streep).

• Ironweed is any plant species of the genus Vernonia.