Interstate 88 is entirely within the state of Illinois. It runs from an intersection with Interstate 80 near Moline, Illinois to an intersection with Interstates 290 and 294 in Hillside, Illinois, near Chicago.

Prior to its designation as an Interstate Highway, the route was known as Illinois state highway 5.

In 2004, IDOT (Illinois Department of Transportation) renamed the freeway portion to the "Ronald Reagan Memorial Freeway." Similarly, the Illinois State Toll Highway Authority renamed the toll portion to "Ronald Reagan Memorial Tollway."

Length

Major cities along the route

• Downers Grove, Illinois
• Naperville, Illinois
• Aurora, Illinois
• DeKalb, Illinois

Intersections with other Interstates

• Interstate 80 near Moline, Illinois
• Interstate 39 in Rochelle, Illinois

Spur routes

None