Interstate 295 is the designation for several Interstate Highways in the United States, all of which are related to Interstate 95:

• Interstate 295 (Florida), a bypass of Jacksonville, Florida
• Interstate 295 (Maine), an alternate route through and north of Portland, Maine
• Interstate 295 (New Jersey) (also in Delaware, and planned to extend into Pennsylvania), a bypass of Philadelphia, Pennsylvania
• Interstate 295 (New York), a connector route in eastern New York, New York
• Interstate 295 (North Carolina), a planned bypass of Fayetteville, North Carolina
• Interstate 295 (Rhode Island) (also in Massachusetts), a bypass of Providence, Rhode Island
• Interstate 295 (Virginia), a bypass of Richmond, Virginia
• Interstate 295 (Washington, D.C.) (also in Maryland), a connector route in Washington, D.C.