The Indiana Toll Road, or more officially the Northern Indiana East-West Toll Road, is a limited access, divided highway in the extreme north of Indiana. It was privately financed and constructed during the 1950s, and user tolls pay for its capital costs and maintenance. It lies throughout its course no more than ten miles from either Lake Michigan or the Michigan state line. It feeds directly into two toll roads at the Illinois and Ohio state lines, the Chicago Skyway in the west and the Ohio Turnpike in the east. All of the Indiana Toll Road is designated as Interstate 90; all of the Toll Road east of the junction of Interstate 80. Interstate 90, and Interstate 94 is also designated as Interstate 80.

Control cities on highway gantries are Chicago, Illinois and Toledo, Ohio, and never South Bend.

Cities and towns for which the Toll Road gives direct access include

• Chicago (continuing to and from the west on Interstate 90)
• Whiting, Indiana and East Chicago, Indiana on U.S. Highway 41
• Hammond, Indiana on Indiana State Route 912 and U.S. 41
• Gary, Indiana on Indiana 912, Indiana State Highway 53 , and Interstate 65
• Portage, Indiana on Interstate 80 to and from the west and Interstate 94
• Valparaiso, Indiana and Chesterton, Indiana on Indiana State Highway 49
• Michigan City, Indiana and Westville, Indiana on U.S. Highway 421
• New Buffalo, Michigan and La Porte, Indiana on Indiana State Highway 39 and Michigan State Highway 239
• South Bend, Indiana and Niles, Michigan on U.S. Highway 31 and Indiana State Highway 933/ Michigan State Highway 51
• Mishawaka, Indiana and Edwardsburg, Michigan on a connector to Indiana State Highway 23 / Michigan State Highway 62
• Elkhart, Indiana on Indiana State Highway 19
• Goshen, Indiana on Indiana State Highway 15
• Constantine, Michigan and Middlebury, Indiana on U.S. Highway 131 and Indiana State Highway 13
• Howe, Indiana , Lagrange, Indiana, and Sturgis, Michigan on Indiana State Highway 9 and Michigan State Highway 66. The Michigan border sign is visible just north of this interchange.
• Angola, Indiana, Auburn, Indiana, and Coldwater, Michigan on Interstate 69

Tolls are collected at barriers near the Ohio state line and in the urban segment between the Illinois state line and Portage, and at interchanges in the sections between Portage and the Ohio state line (tolls collected at exits).