Interstate 440 is the name of three distinct interstate highway spur routes (in Arkansas, Tennessee, and North Carolina) of Interstate 40 in the United States.

Arkansas

Interstate 440 in Arkansas is a 10-mile-long spur route connecting Interstate 40 with Interstate 30 near Little Rock. The spur route, which travels through much of the area's industrial core in the eastern part of the metropolitan area and near Little Rock National Airport, is part of a planned full loop around the metropolitan area, together with Arkansas' Interstate 430. Part of that effort, an extended path from I-440's north end, recently opened as Arkansas Highway 440 and also known as one half of the North Belt Freeway project.

Tennessee

Interstate 440 in Tennessee is an 8-mile-long route connecting Interstate 40 and Interstate 24, bypassing downtown Nashville to the south, completed in 1987.

North Carolina

Interstate 440 in North Carolina, also known as the Raleigh Beltline or Cliff Benson Beltline, is a 16-mile-long loop route circling central Raleigh. Labelled "inner" and "outer," it is one of the only interstate highways in the United States not labelled with compass directions (e.g. east/west). Traffic travels clockwise on the "inner" part of the loop and counterclockwise on the "outer" part of the loop. This designation often leads to confusion when traveling near Raleigh, especially with the addition of the I-540 "Outer Loop". In 2003, the inner/outer labeling was deprecated in favor of east-west designations. The road formally starts at the intersection of Interstate 40 and US 1 near Cary, North Carolina and runs east to the I-40 fork to Benson, North Carolina. The portion of the loop south of Raleigh is not considered part of I-440.