Holmby Hills is a neighborhood in western Los Angeles, California. It is bordered by Beverly Hills on the east, Century City on the southeast, Westwood on the southwest, Bel-Air on the northwest, and Beverly Glen on the north. Sunset Boulevard is the area's principal thoroughfare.

Holmby Hills, Bel-Air, and Beverly Hills form the "Golden Triangle" of Los Angeles' priciest and most exclusive neighborhoods. Holmby Hills is usually considered the wealthiest of the three; many of its estates boast panoramic views of the entire Los Angeles Basin. Many high-level entertainment industry executives, such as Interscope Records founder Jimmy Iovine and Playboy founder Hugh Hefner (whose home is better known as the Playboy Mansion), reside in the area.