Hesperia may refer to:

• One of the Hesperides in Greek mythology
• Hesperia ("Evening land", or "Western land"), a term sometimes applied to Italy and sometimes to Spain
• Hesperia, also called Asterope, the wife or desired lover of Aesacus and daughter of the river Cebren.
• Hesperia, California
• Hesperia, Michigan
• Asteroid 69 Hesperia