Several prominent individuals have been named George Walker:

• Colonel The Reverend George Walker (1645-1690) was an English commander in Ireland.
• George Herbert Walker (1875-1953) was an American businessman and the grandfather of George Herbert Walker Bush.
• George Walker (1922- ) is an African-American composer.
• George Walker (1873-1911) was an African-American vaudeville singer and partner of Bert Williams.
• George Walker was a 19th century U.S. Senator from Kentucky.
• George Walker is a former Major League Baseball player born in Canada.
• George Walker was president of the Canadian Pacific Railway between 1948 and 1955.
• George Walker founded Walker's Point, which later became part of Milwaukee, Wisconsin