Genesis may refer to:

• Genesis – the first book of both the Hebrew Bible (Old Testament)
• Genesis – English progressive rock group
• Genesis - NASA spacecraft
• Sega Genesis and Sega Genesis Nomad – video game consoles
• Genesis LPMud – the original LPMud
• Genesis3D – software library
• GE Genesis – locomotive
• Genesis (web comic)
• Genesis (chess) – chess engine
• Genesis Device – in Star Trek fiction, an experimental terraforming torpedo (see also Project Genesis)
• Genesis Planet – in Star Trek fiction, a planet created by the detonation of the Genesis device
• GENESIS - in Gundam fiction, the Cosmic Era GENESIS superweapon
• Genesis of the Daleks – a Doctor Who serial.
• GENESiS - Genetic-Environemntal Nature of Emotional States in Siblings a large scale genetic study conducted by the University of London