Edwin O. Guthman (born 1919) is a journalist. He was an editor for the Philadelphia Inquirer (1977-1987), a national editor for the Los Angeles Times from 1965 to 1977, a reporter for the Seattle Star (1941-1947), and a reporter for the Seattle Times (1947-1961).

Guthman was born in Seattle, Washington. He entered the Army in 1941. During World War II, he served as an infantry regiment reconnaissance platoon leader in both North Africa and Italy. In 1946, he was discharged as a captain. During his tour, he was awarded the Silver Star and Purple Heart.

He won the Pulitzer Prize for National reporting in 1950. His articles proved that the Washington State Un-American Activities Committee subverted evidence that cleared a University of Washington professor of false charges.

In 1965, he served as Press Secretary for Senator Robert Kennedy.

He was the third person on Nixon's Enemies List.

He is currently (2004) a senior lecturer at University of Southern California in Los Angeles, California, where he has been a professor since 1987.