Dom or DOM may refer to multiple things:

• Document Object Model
• the Dom ethnic group
• 2,5-dimethoxy-4-methylamphetamine (DOM)
• A German word for cathedral, as in Kölner Dom or Berliner Dom. It derives from the latin word "domus" - house/home, and refers to a church as House of God (cf. Italian "Duomo")
• DOM is an acronym that stands for Deo Optimo Maximo : in Latin it means To most good and powerful God and it is carved on the front of many catholic churches. It imitates Roman dedications to Jupiter.
• In French it is a title of respect for monks as in Dom Perignon, analogous to the Italian and Spanish Don.
• Département d'outre-mer, a French overseas département
• The Dominant partner in a BDSM relationship
• The Domination gametype in Unreal Tournament
• The MS-09 Dom or MS-09R Rick Dom mobile suit models from the Mobile Suit Gundam anime.