The hundred of Desborough was one of the three Chiltern Hundreds in Buckinghamshire, England.

The hundred was in the southwest of the county and was bounded by the River Thames to the south and Oxfordshire to the west. To the north it bordered the Aylesbury hundred, and to the east the Burnham hundred.

The main town in the hundred was High Wycombe. Other places include Marlow and Hitchingdon .

There is no place in Desborough hundred named Desborough. There is, however, a Desborough in Northamptonshire. There is a Desborough Hundred Psychogeographical Society founded by writer John Rogers and artist Cathy Rogers.