Delta Connection is the name under which five regional airlines operate routes for mainline carrier, Delta Air Lines.

SkyWest, Atlantic Southeast Airlines, Comair, Chautauqua Airlines, and the American Eagle codeshare flights out of Los Angeles International Airport operate under this name.

On November 2, 2004 Atlantic Coast Airlines ended service as a Delta Connection Carrier. Atlantic Coast Airlines reinvented itself as a low fare carrier called Independence Air based at Washington Dulles Airport.

On December 22, 2004, Delta Air Lines announced that Republic Airways would order and operate 16 Embraer 170 aircraft under the Delta Connection banner.