California State Route 160 is a north-south highway through the inland delta of the Sacramento River between Sacramento, California and Antioch, California (junction California State Route 4 ) through downtown Sacramento. It crosses Business Loop Interstate 80 twice in Sacramento, the more southerly crossing also with U.S. Highway 50. It crosses Interstate 5, but without direct access.

South of Sacramento it takes a scenic, meandering route through the alluvial plain of the lower Sacramento River, meeting California State Route 12 near Rio Vista before it crosses the San Joaquin River on the Antioch Bridge.

Parts of Route 160 in Sacramento are freeway.