In the roleplaying game Warhammer 40000, the Black Rage is one of two fictional genetic faults suffered by the Blood Angels Space Marines.

The Black Rage is described a kind of genetic memory, consisting of the final hours of the Horus Heresy as experienced by the Primarch of the Blood Angels, Sanguinius. The Black Rage is a mental disorder that affects some Blood Angels shortly before battle; the affected Marines believe themselves to actually be Sanguinius, living out his last hours. This drives the affected Marines berserk, enhancing their strength and allowing them to shrug off wounds that would kill even a Space Marine a dozen times over. These unfortunates are grouped together into a suicide squad known as the Death Company and are flung at the enemy, the nature of the Black Rage means that those not fortunate enough to die in battle will die from psychic stress afterwards. The Death Company consists of the most extremely affected, the Black Rage affects all Blood Angels to some degree, which is why their Chapter specialises in close combat.