Bishop 341-B is a fictional character from the Alien series of films, an android created by the Weyland-Yutani corporation and played by Lance Henriksen.

Bishop was the on-board synthetic or "artificial person", as he preferred to be called, on board the colonial marine vessel Sulaco. He did not engage in combat himself, instead acting as both a dropship pilot and scientist. He was the only person qualified to remote-pilot the dropships. Due to his superior hand-eye coordination he was an expert at the exercise of rapidly stabbing between his splayed fingers, which he sometimes did to entertain the Marines. He is stranded with the surviving Marines when their squad is massacured and their 1st Dropship is destroyed. He does research on the Xenomorphs through dead facehuggers, and tells the survivors about the imminent explosion of the Processing Station. Ripley doesn't trust Bishop, but starts to when he volunteers to go out to a subspace transmitter dish to prep and pilot the 2nd Dropship remotely to the planet. He is later split in half by the tail of the Alien Queen, but saves Rebecca "Newt" Jordan, from being sucked into space. This is when Ripley finally trusts Bishop, but their friendship doesn't last, as Bishop is blasted into pieces.

The android was modelled after his creator, Weyland-Yutani robotics engineer Michael Bishop who is the "Bishop II" seen in Alien 3, as confirmed in both the Alien 3 novelization and 2003 DVD commentary for Alien Quadrilogy by Lance Henriksen. However, the more recent spin-off film, Alien vs. Predator has ignored this and established its own canon, which implies the Bishop androids were modelled after Charles Bishop Weyland, and therefore the "real" Bishop is another android rather than a human.

This contradictory mythos seems an indication of separateness of the Alien and Alien vs. Predator film series - not designed as part of the same universe, the canon of one series therefore would not linked to the canon of the other. Another option is that Michael Bishop is perhaps a descendant of Charles Bishop Weyland. Neither option has been officially confirmed.