Anna Maria Luisa de' Medici, (1667-1743), was the last of the Medicis.

She was the daughter of Cosimo III de' Medici, Grand Duke of Tuscany and Marguerite Louise d'Orléans and the sister of Gian Gastone de' Medici, Grand Duke of Tuscany, the last Medici grand duke of Tuscany.

She married Johann Wilhelm, Elector Palatine (1658-1716).

Her most notable action was willing all the personal property of the Medicis to the Florentine state, provided that nothing was ever removed from Florence.