The Mohawk Nation of Akwesasne is a Mohawk Nation territory located across the intersection of the New York-Ontario-Quebec borders on the south bank of the St. Lawrence River. It includes the mouths of both the Raquette River and the St. Regis River and a number islands in all three of the rivers.

In New York, Akwesasne coincides with the St. Regis Indian Reservation.

The name Akwesasne means "Land Where the Partridge Drums."